Classic psychedelic
3,4,5-trimethoxyphenethylamine
Sacred to Native American tribes for over 5,000 years. Used in religious ceremonies and healing rituals.
At a glance
Reported effects
Legal status
Controlled substance, but peyote use protected for registered Native American Church members in US.
Research
Limited modern research, but historical studies show therapeutic potential.
Johnson MW, et al. · Pharmacology & Therapeutics · 2019
Broad review of classic psychedelics covering population studies, early clinical trials, mystical experience and brain imaging, as of 2019.
What the study foundKrebs TS, et al. · PLoS ONE · 2013
US survey of 130,152 adults: lifetime psychedelic use was not linked to higher rates of mental health problems.
What the study foundHalpern JH, et al. · Biological Psychiatry · 2005
Navajo Native American Church members who regularly use peyote showed no mental health or cognitive deficits compared with non-users.
What the study foundThe dispatch
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